I wouldn't qualify it as a "negative effect"! On the contrary, in the first phase following the spiritual awakening, distancing ourselves from everything and everyone seems to be the very first pre-requisite to start our serious innerw-work and healing so that we may start aligning the still very distorted and unhealthy subconscious program with the just awakened spirit! A people-pleaser or codependent person, for instance, would never be able to stop saying yes at their expense, should they still be surrounded by their old circle.
"Perhaps the most common center today is the self. The most obvious form is selfishness, which violates the values of most people.
But if we look closely at many of the popular approaches to growth and self-fulfillment, we often find self-centering at their core.
There is little security, guidance, wisdom, or power in the limited center of self. Like the Dead Sea in Palestine, it accepts but never gives. It becomes stagnant.
On the other hand, paying attention to the development of self in the greater perspective of improving one's ability to serve, to produce, to contribute in meaningful ways, gives context for dramatic increase in the four life-support factors." ~ Stephen R. Covey